Correlation of non-random chromosomal aberrations in lymphocytes of prostate cancer patients with specific clinical parameters

The purpose of this research was to correlate non-random chromosomal aberra tions in the peripheral blood lymphocytes (PBLs) of prostate cancer patient s with specific clinical parameters. Peripheral blood samples were analyzed from 59 informative prostate cancer patients. Non-random chromosomal alter ations detected in the PBLs and their correlation with any specific clinica l parameters were analyzed statistically. A comparison was made between spe cific chromosomal abnormalities in the patients having an early (<65 years) or late (greater than or equal to 65 years) age at disease onset, low-grad e (Gleason grade <7) or high-grade (Gleason grade greater than or equal to 7) turners, a low (<10 ng/ml) or high (greater than or equal to 10 ng/ml) p rostate-specific antigen (PSA) level, and androgen-sensitive or -insensitiv e disease. In examining the specific chromosomal breakpoints, the regions 1 p13, 2q21, 3p21, 4q13, 5q31, 6p21, 7p15, 7p13, 7q32, 10p11, 10q26, 11p15, 1 1p11, 14q12, and 16q12 showed breaks in at least four cases. Chromosome 15 (P=0.045) was significantly altered in patients having a PSA value greater than or equal to 10, while it (P=0.017) and chromosome 19 (P=0.036) were si gnificantly altered in patients having a PSA value greater than or equal to 20. In addition, chromosomes 5 (P=0.032), 8 (P=0.020), 16 (P=0.009), and 2 0 (P=0.047) were significantly altered in patients having a Gleason grade g reater than 7. Also, chromosomes 2 (P=0.020) and 3 (P=0.044) were significa ntly altered in patients who had early disease onset. Additionally, chromos ome 10 (P=0.041) was significantly altered in patients having metastasis, a nd chromosomes 4 (P=0.006) and 7 (P=0.028) were significantly altered in pa tients having androgen-insensitive disease. In spite of the small subset of patients, chromosome 8 (P=0.003) was significantly altered in patients hav ing small cell carcinoma of the prostate. From these results we conclude th at nonrandom chromosomal aberrations present in PBLs of prostate cancer pat ients can be correlated with specific clinical parameters. These correlatio ns can be used to identify a prostate cancer patient's risk response to the rapy.