Soluble CD14 in children with status asthmaticus

Background: Inflammation is a major component in the pathogenesis of asthma . CD14 is an endotoxin (lipopolysaccharide) receptor, and is expressed main ly on monocytes and macrophages. Binding of LPS to CD14 activates the monoc yte or macrophage and causes the release of different cytokines. The solubl e form of CD14 is present in serum, and its concentration increases in seve ral clinical conditions, including infections, auto-immune disorders, aller gic disorders, and lung diseases. The possible role of CD14/sCD14 in asthma has been investigated in a few adult patients only. Objectives: To measure serum concentrations of sCD14 in children with statu s asthmaticus. Methods: We compared serum concentration of sCD14 in 10 children with statu s asthmaticus measured within 24 hours Of admission and after recovery from the acute episode. Results: Levels of sCD14 were significantly higher during acute asthma atta cks than at recovery. Conclusions: The elevated serum levels of sCD14 during status asthmaticus m ay be the result of the activation of monocytes, macrophages or other cells . The influence of medications on serum sCD14 cannot be ruled out. The poss ible use of sCD14 as a marker of lung inflammation in asthma warrants furth er investigation.