Background: Erythema nodosum, although uncommon in children, is the most fr
equent form of panniculitis in pediatrics. EN has been associated with vari
ous infections and chronic inflammations, and its course varies with age, g
ender, and racial and geographic factors. There is no information on EN in
Israeli children.
Objectives: To examine the clinical course of EN and the conditions with wh
ich it is associated in Israeli children.
Methods: We conducted a retrospective study of 24 children with a diagnosis
of EN who presented at our Center over a 10 year period (1989-98).
Results: EN was more frequent in females than males (ratio 2:1) due to a cl
uster of adolescent girls. The mean duration of the skin manifestation was
18 days. The course was benign in all patients. Streptococcal infection was
the most common cause (25%), followed by Epstein-Barr virus infection (18%
) and inflammatory bowel disease (13%). In one-third of cases, no specific
cause could be identified. Tuberculosis, an important cause of EN in the pa
st, was not found in our patients.
Conclusions: Most cases of EN in Israeli children are related to streptococ
cal and EBV infections or to chronic inflammatory conditions. Despite the i
ncrease in tuberculosis morbidity in Israel during recent years, we found n
o association of EN and tuberculosis in our study.