Pregnancy outcome in women with primary renal disease

Background: The preconception and intraconception parameters that are relev ant to outcome in women with underlying renal disease remain controversial. Objectives: To analyze the types and frequencies of shoft- and long-term (2 years after delivery) maternal and neonatal complications in 38 patients w ith primary renal disease (46 pregnancies), most of them with mild renal in sufficiency. Methods: Logistic regression models were formulated to predict successful o utcome. Results: Successful pregnancy outcome (live, healthy infant without severe handicap 2 years after delivery) was observed in 98% of the patients with p rimary renal disease. Factors found to be significantly predictive of succe ssful outcome were absence of pre-existing hypertension, in addition to low preconception serum uric acid level. Conclusions: Most women with primary renal disease who receive proper prena tal care have a successful pregnancy outcome. Worse pregnancy outcome was o bserved in women with moderate or severe renal failure. Fitted logistic mod els may provide useful guidelines for counseling women with preexisting ren al disease about their prospects for a successful pregnancy in terms of imm ediate and long-term maternal and neonatal outcome.