Magnetic resonance first-pass myocardial perfusion imaging: Clinical validation and future applications

Clinical studies suggest that magnetic resonance first-pass (MRFP) perfusio n imaging is comparable to current diagnostic tests that are used clinicall y for the assessment of myocardial perfusion. In addition, magnetic resonan ce imaging (MRI) perfusion imaging is a noninvasive method for determining myocardial blood now. The spatial resolution (in-plane spatial resolution < 3 mm) is sufficient to differentiate between subendocardial perfusion and subepicardial perfusion. The measurement can be repeated regularly without any adverse effects for the patient. MRT perfusion measurements can be comb ined with the evaluation of global function and regional wall thickening. C urrently, there is no other imaging technique that offers similar advantage s. The MRI perfusion measurements can be carried out during baseline condit ions and during maximal hyperemia induced with either adenosine or dipyrida mole. The ratio of the measured myocardial blood flows provides an estimate of the absolute and relative myocardial perfusion reserve, The perfusion r eserve determined with MRFP imaging is a quantitative measure for the asses sment of the collateral-dependent myocardial now. Based on the available da ta using MRFP perfusion imaging, the current clinical first-line perfusion imaging tests are going to he challenged in the near future, (C) 1999 Wiley -Liss, Inc.