Nm. Wilke et al., Magnetic resonance first-pass myocardial perfusion imaging: Clinical validation and future applications, J MAGN R I, 10(5), 1999, pp. 676-685
Clinical studies suggest that magnetic resonance first-pass (MRFP) perfusio
n imaging is comparable to current diagnostic tests that are used clinicall
y for the assessment of myocardial perfusion. In addition, magnetic resonan
ce imaging (MRI) perfusion imaging is a noninvasive method for determining
myocardial blood now. The spatial resolution (in-plane spatial resolution <
3 mm) is sufficient to differentiate between subendocardial perfusion and
subepicardial perfusion. The measurement can be repeated regularly without
any adverse effects for the patient. MRT perfusion measurements can be comb
ined with the evaluation of global function and regional wall thickening. C
urrently, there is no other imaging technique that offers similar advantage
s. The MRI perfusion measurements can be carried out during baseline condit
ions and during maximal hyperemia induced with either adenosine or dipyrida
mole. The ratio of the measured myocardial blood flows provides an estimate
of the absolute and relative myocardial perfusion reserve, The perfusion r
eserve determined with MRFP imaging is a quantitative measure for the asses
sment of the collateral-dependent myocardial now. Based on the available da
ta using MRFP perfusion imaging, the current clinical first-line perfusion
imaging tests are going to he challenged in the near future, (C) 1999 Wiley
-Liss, Inc.