Phosphorelay as the sole physiological route of signal transmission by thearc two-component system of Escherichia coli

Authors
Kwon, O Georgellis, D Lin, ECC
Citation
O. Kwon et al., Phosphorelay as the sole physiological route of signal transmission by thearc two-component system of Escherichia coli, J BACT, 182(13), 2000, pp. 3858-3862
Citations number
30
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF BACTERIOLOGY
ISSN journal
00219193 → ACNP
Volume
182
Issue
13
Year of publication
2000
Pages
3858 - 3862
Database
ISI
SICI code
0021-9193(200007)182:13<3858:PATSPR>2.0.ZU;2-Y
Abstract
The Are two-component system, comprising a tripartite sensor kinase (ArcB) and a response regulator (ArcA), modulates the expression of numerous genes involved in respiratory functions. In this study, the steps of phosphoryl group transfer from phosphorylated ArcB to ArcA were examined in vivo by us ing single copies of wild-type and mutant arcB alleles, The results indicat e that the signal transmission occurs solely by His-Asp His-Asp phosphorela y.