A rapid and efficient one-pot synthesis of substituted 2-(5 H)-furanones under focused microwave irradiations

Authors
Liao, L Villemin, D
Citation
L. Liao et D. Villemin, A rapid and efficient one-pot synthesis of substituted 2-(5 H)-furanones under focused microwave irradiations, J CHEM R-S, (4), 2000, pp. 179-181
Citations number
14
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF CHEMICAL RESEARCH-S
ISSN journal
03082342 → ACNP
Issue
4
Year of publication
2000
Pages
179 - 181
Database
ISI
SICI code
0308-2342(200004):4<179:ARAEOS>2.0.ZU;2-5
Abstract
3-Hydroxy-3-methyl-2-butanone 1 reacted with ethyl cyanocetate in 2 in the presence of sodium ethoxide under focused microwave irradiations to afford 3-cyano-4,5,5-trimethyl-2-(5H)-furanone 3. Furanone 3 then condensed with a romatic or heteroaromatic aldehydes 4a-h to produce 3-cyano-4-(trans-aryl-v inyl)-5,5-dimethyl-2-(5H)-furanones 5a-h in high overall yields (71-88%).