This study explored the clinical and psychosocial predictors of work adjust
ment in 52 Bipolar I patients over a 2-year longitudinal period and examine
d associations between work functioning and social relationships, personali
ty features, stressful life events, and clinical variables. Analyses indica
ted that psychosocial variables (personality disorder symptoms and social f
unctioning) added significantly to prediction of work functioning after cli
nical variables were entered. Stressful life events were not associated wit
h work adjustment. Overall, presence of a good quality supportive relations
hip was the strongest unique predictor of work. The results highlight the n
eed to study functional outcomes in patients, especially because they appea
r only modestly associated with clinical status.