A novel hepatitis C virus (HCV) subtype from Somalia and its classification into HCV clade 3

Hepatitis C virus (HCV) sequences from throughout the world have been group ed into six clades, based on recently proposed criteria. Here, the partial sequences and clade assignment are reported for three HCV isolates from chr onic hepatitis C patients from Somalia, for whom conventional assays failed to identify the genotype, Phylogenetic analysis of the sequences of the co re, envelope 1 and part of the non-structural 5b regions suggests that all three isolates belong to a distinct: HCV genetic group, tentatively classif ied as subtype 3h, This novel HCV subtype shows the highest sequence simila rity with HCV isolates from Indonesia. Despite the fact that these patients were infected with HCV clade 3, none of them responded to standard interfe ron treatment.