The purpose of this study was to determine the impact of intraoperativ
e ultrasound (IOUS) on the management of patients with neoplasms of th
e liver. Fifty-nine patients with liver neoplasms (primary, 6; metasta
tic, 53) and without pre- or intraoperative evidence of extrahepatic d
isease underwent laparotomy for possible liver resection. Preoperative
imaging studies included external ultrasound (n = 12), magnetic reson
ance imaging (n = 11), and/or computed tomography (n = 57). Intraopera
tive evaluation on all patients included inspection, bimanual palpatio
n, and ultrasonography. External ultrasound, magnetic resonance imagin
g, and computed tomography identified all intraoperatively confirmed l
iver neoplasms in 33, 45, and 67 per cent of eases, respectively. Unsu
spected neoplasms were identified in 12 patients (20%) by inspection/p
alpation and in 19 patients (32%) by IOUS. In eight patients (14%), th
e occult neoplasms were identified only by IOUS, and in one patient th
e neoplasms were identified only by inspection/palpation. Occult neopl
asms identified by IOUS were characterized by small size (less than 2
cm). Findings from the intraoperative evaluation, such as unsuspected
neoplasms and vascular proximity or invasion, altered the preoperative
plan in 20 (34%) patients. Inspection, and particularly palpation, id
entifies a number of preoperatively unsuspected liver neoplasms. Intra
operative ultrasound, however, is the most sensitive method for detect
ion of liver neoplasms and influences the operative management in a su
bstantial number of patients.