8-Difluoromethoxy-4-quinolone derivatives as anti-feline immunodeficiency virus (FIV) agents: Important structural features for inhibitory activity of FIV replication

The inhibitory activities of various 8-difluoromethoxy-4-quinolone derivati ves against feline immunodeficiency virus (FIV) replication in the chronica lly infected cell line P-CrFK were investigated. Certain derivatives were f ound to inhibit FIV production from P-CrFK cells in a dose-dependent manner without exhibiting cytotoxic effects at inhibitory concentrations. Based o n this study, the structures important for anti-FIV activity are suggested to be (i) a carboxyl group at position C-3, and (ii) an aromatic modificati on at position 4 of the C-7 piperazinyl moiety.