Pharmacological implications of lengthened in-utero exposure to nevirapine

Authors
Taylor, GP Lyall, EGH Back, D Ward, C Tudor-Williams, G
Citation
Gp. Taylor et al., Pharmacological implications of lengthened in-utero exposure to nevirapine, LANCET, 355(9221), 2000, pp. 2134-2135
Citations number
5
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
LANCET
ISSN journal
01406736 → ACNP
Volume
355
Issue
9221
Year of publication
2000
Pages
2134 - 2135
Database
ISI
SICI code
0140-6736(20000617)355:9221<2134:PIOLIE>2.0.ZU;2-Q
Abstract
Given as a single dose to the mother during labour, nevirapine can protect the neonate from HIV-1 infection for up to 7 days, However, after maternal nevirapine therapy during pregnancy, neonatal plasma concentrations of nevi rapine decline more rapidly, suggesting in-utero liver enzyme induction.