Detection of the interleukin 18 family in rat brain by RT-PCR

Authors
Wheeler, RD Culhane, AC Hall, MD Pickering-Brown, S Rothwell, NJ Luheshi, GN
Citation
Rd. Wheeler et al., Detection of the interleukin 18 family in rat brain by RT-PCR, MOL BRAIN R, 77(2), 2000, pp. 290-293
Citations number
25
Categorie Soggetti
Neurosciences & Behavoir
Journal title
MOLECULAR BRAIN RESEARCH
ISSN journal
0169328X → ACNP
Volume
77
Issue
2
Year of publication
2000
Pages
290 - 293
Database
ISI
SICI code
0169-328X(20000505)77:2<290:DOTI1F>2.0.ZU;2-Q
Abstract
Interleukin 18, an inflammatory cytokine, mediates its effects by interacti on with its receptor complex, consisting of the IL-18 receptor (IL-18R) and receptor accessory protein (AcPL). A functional inhibitor of IL-18, the IL -18 binding protein (IL-18BF), has been identified recently. This study rep orts the detection of IL-18, IL-18R, AcPL and IL-18BP mRNA expression in th e brain of normal adult rats using RT-PCR. (C) 2000 Elsevier Science B.V. A ll rights reserved.