Chronic unilateral ureteral obstruction represented as renin-dependent hypertension

A 50-year-old woman developed renin-dependent hypertension immediately afte r accidental unilateral ureteral ligation during hysterectomy, and the hype rtension lasted for 5 months. Surgical release of the obstruction was carri ed out 157 days after the ligation. Then, her blood pressure was normalized . However, the obstructed kidney showed intensive tubulointerstitial fibros is and functional recovery was not obtained. This case suggests that the re nin-angiotensin system may be upregulated in human kidney during unilateral ureteral obstruction for a long duration. Copyright (C) 2000 S. Karger AG. Basel.