A novel stereocontrolled synthesis of 1,2-trans cyclopropyl ketones via Suzuki-type coupling of acid chlorides with cyclopropylboronic acids

Authors
Chen, H Deng, MZ
Citation
H. Chen et Mz. Deng, A novel stereocontrolled synthesis of 1,2-trans cyclopropyl ketones via Suzuki-type coupling of acid chlorides with cyclopropylboronic acids, ORG LETT, 2(12), 2000, pp. 1649-1651
Citations number
37
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
12
Year of publication
2000
Pages
1649 - 1651
Database
ISI
SICI code
1523-7060(20000615)2:12<1649:ANSSO1>2.0.ZU;2-H
Abstract
[GRAPHICS] The palladium-catalyzed cross-coupling reaction of cyclopropylboronic acids with acyl chlorides was achieved by the combination of Ag2O and K2CO3 as t he base. Highly enantiomerically enriched cyclopropyl ketones (ee >90%) wer e also obtained by the reaction of corresponding chiral cyclopropylboronic acids.