[4+1] cycloaddition of bis(alkylthio)carbenes with vinyl isocyanates. Total synthesis of (+/-)-mesembrine

Authors
Rigby, JH Dong, WT
Citation
Jh. Rigby et Wt. Dong, [4+1] cycloaddition of bis(alkylthio)carbenes with vinyl isocyanates. Total synthesis of (+/-)-mesembrine, ORG LETT, 2(12), 2000, pp. 1673-1675
Citations number
31
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
12
Year of publication
2000
Pages
1673 - 1675
Database
ISI
SICI code
1523-7060(20000615)2:12<1673:[COBWV>2.0.ZU;2-E
Abstract
[GRAPHICS] The Sceletium alkaloid mesembrine has been synthesized in 13% overall yield by a sequence featuring a [4 + 1] cycloaddition of a bis-(alkylthio)carben e with a functionalized vinyl isocyanate.