Solid-phase synthesis of cyclic peptide-DNA hybrids

Authors
Bleczinski, CF Richert, C
Citation
Cf. Bleczinski et C. Richert, Solid-phase synthesis of cyclic peptide-DNA hybrids, ORG LETT, 2(12), 2000, pp. 1697-1700
Citations number
36
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
12
Year of publication
2000
Pages
1697 - 1700
Database
ISI
SICI code
1523-7060(20000615)2:12<1697:SSOCPH>2.0.ZU;2-B
Abstract
[GRAPHICS] A methodology for preparing cyclic peptide-DNA hybrids on controlled pore g lass in high yield is reported. This methodology employs Fmoc/Alloc-protect ed amino acid and nucleoside phosphoramidites on an omega-hydroxylauric aci d-derivatized support and is suitable for library synthesis. A cyclic hybri d of the sequence Glu-Leu-T*T-DP-Lys, where Glu and Lys are linked and T* d enotes a 5'-amino-5'-deoxynucleotide, exhibited high resistance to exo- and endonucleases.