A new approach to macrocyclization via alkene formation in catalytic diazodecomposition. Synthesis of patulolides A and B

Authors
Doyle, MP Hu, WH Phillips, IM Wee, AGH
Citation
Mp. Doyle et al., A new approach to macrocyclization via alkene formation in catalytic diazodecomposition. Synthesis of patulolides A and B, ORG LETT, 2(12), 2000, pp. 1777-1779
Citations number
31
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
12
Year of publication
2000
Pages
1777 - 1779
Database
ISI
SICI code
1523-7060(20000615)2:12<1777:ANATMV>2.0.ZU;2-A
Abstract
[GRAPHICS] Effective synthetic uses of bisdiazocarbonyl compounds for the selective co nstruction of diverse macrocycles, including the synthesis of patulolides A and a, by catalytic "carbene dimer" formation are reported. Control of ste reochemistry and efficient methods for product isomerization or kinetic iso mer differentiation have been achieved.