Solitary fibrous tumor of the vagina

The solitary fibrous tumor (SFT) is a rare tumor that most commonly arises in the pleura. Recent evidence has indicated that this tumor originates fro m mesenchymal, probably fibroblastic, cells and is not restricted to the pl eura. However, its occurrence in the female genital tract is extremely rare . We report a case of primary SFT that originated from the vagina in a 34-y ear-old female. It was a pedunculated polypoid tumor and occurred at the si te of scar tissue, caused by laceration during her last labor 7 years previ ously. Histologically, the tumor was predominantly composed of a random pro liferation of spindle cells, intimately admixed with collagen. Immunohistoc hemically, the cells were strongly positive for CD34, vimentin and bcl-2, b ut were negative for S-100 protein, neuron-specific enolase, smooth muscle actin, desmin, CD68, cytokeratins and epithelial membrane antigen. To the b est of our knowledge, this is the first reported case of a primary vaginal SFT in the English literature. Our report suggests to include SFT in the di fferential diagnosis of a spindle cell neoplasm originating from the vagina .