Sb. Kater et A. Shibata, THE UNIQUE AND SHARED PROPERTIES OF NEURONAL GROWTH CONES THAT ENABLENAVIGATION AND SPECIFIC PATHFINDING, J PHYSL-PAR, 88(3), 1994, pp. 155-163
The neuronal growth cone has as one of its primary functions the role
of guiding the elongating neurite to its appropriate target. The event
s during pathfinding require that the neuronal growth cone responds to
particular molecules in the environment by making appropriate changes
in the behavior of the growth cone. This paper discusses the role of
intracellular calcium as a signalling system mediating these responses
. The specific roles of the growth cone filopodia in acting as antenna
e in advance of the motile growth cone are discussed in the context of
calcium mediated pathfinding events.