El. Molnar et al., Biosynthesis of interleukin-6, an autocrine growth factor for melanoma, isregulated by melanoma-derived histamine, SEM CANC B, 10(1), 2000, pp. 25-28
Interleukin-6 is an autocrine growth factor in advanced stage melaloma and
biosynthesis of IL-6 is increased by histamine in various cell lines. In ou
r study we analysed the direct relation of histamine and IL-6 synthesis in
human melanoma cell lines. All melanoma cells contained IL-G mRNA, but only
metastatic melanoma cells secreted the IL-G protein. The HI histamine rece
ptor antagonist triprolidine decreased gene expression and biosynthesis of
IL-6, while other histamine receptor antagonists had no effect. These data
indicate that endogeneous histamine has a definite role in the regulation o
f local a-G, suggesting that histamine and IL-6 could be part of autocrine
growth regulation of the tumor.