Noncaseating granulomatous disease in common variable immunodeficiency

Patients with common variable immunodeficiency (CVID) are occasionally reco gnized to have a concurrent noncaseating granulomatous disease. The ganulom atous disease (GD) associated with CVID shares many clinical properties typ ical of sarcoidosis. Some investigators speculate that the GD-CVID is actua lly sarcoidosis that is expressed atypically because of the patient's immun odeficiency. Clinical differences, however, have led other investigators to speculate that the GD-CVID is a distinct "sarcoid-like" granulomatous proc ess.