LNB-TM7, a group of seven-transmembrane proteins related to family-B G-protein-coupled receptors

Citation
M. Stacey et al., LNB-TM7, a group of seven-transmembrane proteins related to family-B G-protein-coupled receptors, TRENDS BIOC, 25(6), 2000, pp. 284-289
Citations number
46
Categorie Soggetti
Biochemistry & Biophysics
Journal title
TRENDS IN BIOCHEMICAL SCIENCES
ISSN journal
09680004 → ACNP
Volume
25
Issue
6
Year of publication
2000
Pages
284 - 289
Database
ISI
SICI code
0968-0004(200006)25:6<284:LAGOSP>2.0.ZU;2-S
Abstract
A number of unusual seven-transmembrane molecules have recently been charac terized that have significant amino acid sequence similarity within the mem brane-spanning hydrophobic regions and intervening loops to members of G-pr otein-coupled receptor family B. However, in contrast to the family-B G-pro tein-coupled receptors, these molecules have unusually large N-terminal ext racellular domains that contain a number of well-characterized protein modu les. The range of cell types expressing these complex molecules and their p otential roles in cell adhesion and signalling have become a major focus of research in a number of biological systems.