Evaluation of Protein S-100 serum concentrations in healthy newborns and seven newborns with perinatal acidosis

We measured Protein S-100 serum levels in 66 healthy newborns during the fi rst week of life and in 7 newborns with perinatal acidosis. Normal values ( n = 66) constantly ranged between 0.66 and 3.33 mu g/l (2.5 and 97.5 percen tiles) during the evaluation period. Conclusions: Newborns with signs of hypoxic-ischaemic encephalopathy (HIE) after perinatal acidosis showed elevated Protein S-100 serum levels, wherea s newborns without these signs had normal concentrations. S-100 might thus be a marker of central nervous system damage in newborns.