NEW 4-ARYLAMINOPIPERIDINES WITH ANTIHYPOXIC AND ANTICONVULSIVE ACTIVITY

Authors
DOMANY G BARTASZALAI G PALOSI E SZABO S SCHON I
Citation
G. Domany et al., NEW 4-ARYLAMINOPIPERIDINES WITH ANTIHYPOXIC AND ANTICONVULSIVE ACTIVITY, Arzneimittel-Forschung, 44-2(9), 1994, pp. 989-991
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
44-2
Issue
9
Year of publication
1994
Pages
989 - 991
Database
ISI
SICI code
0004-4172(1994)44-2:9<989:N4WAAA>2.0.ZU;2-O
Abstract
Several new bioanalogues of (+/-)-N-methyl-N-{1-[3-(4-fluorophenoxy) - 2- hydroxy -propyl]piperidin -4- yl} benzothiazol-2-amine (1, sabeluzo le, CAS 104383-17-7) were prepared by reacting 1,2-epoxy-3-aryloxyprop anes with 4-arylamninopiperidines. Some of these derivatives showed en hanced activity in the potassium cyanide hypoxia test and in the pente trazol convulsion test in mice compared to 1.