Serial analysis of MLL-AF4 chimeric message through successful bone marrowtransplantation in a patient with t(4;11)-positive infant-ALL

Authors
Tabata, Y Hibi, S Maruyama-Tabata, H Tsunamoto, K Todo, S Sawada, T Okamura, T Kawa-Ha, K Imashuku, S
Citation
Y. Tabata et al., Serial analysis of MLL-AF4 chimeric message through successful bone marrowtransplantation in a patient with t(4;11)-positive infant-ALL, AM J HEMAT, 64(3), 2000, pp. 203-205
Citations number
15
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF HEMATOLOGY
ISSN journal
03618609 → ACNP
Volume
64
Issue
3
Year of publication
2000
Pages
203 - 205
Database
ISI
SICI code
0361-8609(200007)64:3<203:SAOMCM>2.0.ZU;2-P
Abstract
A 28-month-old girl with acute lymphoblastic leukemia (ALL) showing a t(4;1 1)(q21;q23) karyotype successfully underwent allogeneic bone marrow transpl antation (BMT) at relapse. The chimeric MLL-AF4 message on her bone marrow (BM) specimens, examined by reverse transcriptase-polymerase chain reaction , was detectable at diagnosis, relapse, and just before BMT but became unde tectable following BMT, She has since maintained complete remission. This o bservation suggests that detection of the chimeric message in BM may be use ful to predict clinical outcome in patients with t(4;11). (C) 2000 Wiley-Li ss, Inc.