Y. Tabata et al., Serial analysis of MLL-AF4 chimeric message through successful bone marrowtransplantation in a patient with t(4;11)-positive infant-ALL, AM J HEMAT, 64(3), 2000, pp. 203-205
A 28-month-old girl with acute lymphoblastic leukemia (ALL) showing a t(4;1
1)(q21;q23) karyotype successfully underwent allogeneic bone marrow transpl
antation (BMT) at relapse. The chimeric MLL-AF4 message on her bone marrow
(BM) specimens, examined by reverse transcriptase-polymerase chain reaction
, was detectable at diagnosis, relapse, and just before BMT but became unde
tectable following BMT, She has since maintained complete remission. This o
bservation suggests that detection of the chimeric message in BM may be use
ful to predict clinical outcome in patients with t(4;11). (C) 2000 Wiley-Li
ss, Inc.