Ym. Van Kasteren et al., Incipient ovarian failure and premature ovarian failure show the same immunological profile, AM J REPROD, 43(6), 2000, pp. 359-366
PROBLEM: Incipient ovarian failure (IOF) is characterized by regular menstr
ual cycles, infertility and a raised early-follicular FSH in women under 40
. IOF might be a precursor or a mitigated form of premature ovarian failure
(POF). Disturbances in the immune system may play a role in ovarian failur
e.
METHOD OF STUDY: Autoantibodies and lymphocyte subsets were determined in 3
POF patients, 50 IOF patients, and 27 controls.
RESULTS: The prevalence of autoantibodies did not differ between the groups
. There was a statistically significant difference in lymphocyte subsets be
tween the control group and the POF group, with the IOF group taking an int
ermediate position. We found a decrease in percentage of T-suppressor cells
with a rise in T-helper/T-suppressor cell ratio, a decrease in natural kil
ler cells, and an increase in B lymphocytes and HLA-DR positive T cells.
CONCLUSIONS: These data support the concept that IOF is a mitigated form of
POF. The question remains whether these changes are the cause or the conse
quence of the ovarian failure.