Potentiometric and coulometric determination of carbimazole

Authors
Ciesielski, W Krenc, A
Citation
W. Ciesielski et A. Krenc, Potentiometric and coulometric determination of carbimazole, ANAL LETTER, 33(8), 2000, pp. 1545-1554
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
ANALYTICAL LETTERS
ISSN journal
00032719 → ACNP
Volume
33
Issue
8
Year of publication
2000
Pages
1545 - 1554
Database
ISI
SICI code
0003-2719(2000)33:8<1545:PACDOC>2.0.ZU;2-Z
Abstract
A method for the determination of carbimazole involving its reaction with i odine in an alkaline medium is presented. In volumetric titration with pote ntiometric end-point detection the range of determination is 30-500 mu mol (5.6-93 mg). In coulometric titration using biamperometric end-point detect ion, 0.5-20 mu mol (0.09-3.7 mg) of carbimazole was successfully determined . The coulometric titration was applied to the determination of carbimazole in tablets.