Fatal anaphylactic reaction to protamine after femoropopliteal by-pass surgery

Background and Aims: Administration of protamine might cause serious compli cations especially in patients treated preoperatively with NPH insulin. Material and Methods: A case report. Results and Conclusion: Administration of protamine sulphate caused fatal a naphylactic reaction to a diabetic patient undergoing femoropopliteal by-pa ss surgery. Care should be taken when administering protamine to a patient treated preoperatively with NPH insulin and the possibility of an anaphylac tid reaction to protamine have to be kept in mind.