This paper reviews the emergence of telemedicine and its recent expansion a
nd use within the healthcare industry. Through this review, several example
s of telemedicine within a variety of applications provide a broad context
to discuss the challenges and opportunities facing the emergence of e-medic
ine. These examples provide snapshots of a teleradiology system used by the
military, teleconsultations used in neurosurgery and hemodialysis, and hom
e telemedicine used in diabetes care. Based on the discussion of telemedici
ne's history and expansion and the examples provided, a framework is offere
d for understanding the evolution of telemedicine applications through four
stages. These stages include: (a) development of basic technological capab
ilities, (b) development of relevant applications, (c) the integration of t
echnical applications within a complex environment, and (d) transformation
of the operating environment. Implications for this framework are discussed
.