To determine the distribution of molecular gas at high Galactic latitudes,
nearly one-half of the southern Galactic hemisphere at b less than or equal
to -30 degrees was surveyed in the CO (1-0) transition at 115 GHz. The sam
pling was done on a locally Cartesian grid with 1 degrees (true angle) spac
ing in Galactic longitude and latitude. Of the 11,478 points in the grid, t
he 4982 that rise above an elevation of 30 degrees in Cambridge, Massachuse
tts, the site of the 1.2 m millimeter-wave telescope used for the survey, w
ere observed to an rms of T-A* similar to 0.1 K. We found 144 distinct CO (
1-0) emission lines along 133 lines of sight. Of these detections, 58 are n
ew and 75 are associated with 26 previously cataloged high-latitude molecul
ar clouds situated within the survey boundaries. The surface filling factor
of molecular gas is 0.03, a factor of 10 greater than that found in the no
rthern Galactic hemisphere at b greater than or equal to +30 degrees. On th
e assumption that the CO/H-2 ratio [N(H-2)/W(CO)] is given by 1.0 x 10(20)
cm(-2) (K km s(-1))(-1), the mass surface density of molecular gas in the r
egion of the survey is 0.09 M. pc(-2). The Gaussian scale height of the 133
detections is similar to 100 pc, consistent with that determined for lower
latitude dark clouds.