A polymorphism upstream from the human paraoxonase (PON1) gene and its association with PON1 expression

Authors
Suehiro, T Nakamura, T Inoue, M Shiinoki, T Ikeda, Y Kumon, Y Shindo, M Tanaka, H Hashimoto, K
Citation
T. Suehiro et al., A polymorphism upstream from the human paraoxonase (PON1) gene and its association with PON1 expression, ATHEROSCLER, 150(2), 2000, pp. 295-298
Citations number
17
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
ATHEROSCLEROSIS
ISSN journal
00219150 → ACNP
Volume
150
Issue
2
Year of publication
2000
Pages
295 - 298
Database
ISI
SICI code
0021-9150(200006)150:2<295:APUFTH>2.0.ZU;2-Z
Abstract
Human serum paraoxonase (PON1) is an esterase that has been shown to decrea se the susceptibility of lipoproteins to lipid peroxidation. We found a pol ymorphism of cytosine/thymidine (- 108C/T, the number is from the ATG codon ) in the upstream region of the PON1 gene. The luciferase activity was lowe r in the - 108T allele than in the - 108C allele. The serum PONI concentrat ions in 132 normal subjects were as follows: - 108CC > - 108CT and > - 108T T genotypes. The polymorphism upstream from the PON1 gene is associated wit h transcription of the PON1 gene and the serum PON1 concentration. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.