A new preparation of the diastereoisomeric N-acetylneuraminic alditols

Authors
Ooi, HC Marcuccio, SM Jackson, WR
Citation
Hc. Ooi et al., A new preparation of the diastereoisomeric N-acetylneuraminic alditols, AUST J CHEM, 53(3), 2000, pp. 171-174
Citations number
5
Categorie Soggetti
Chemistry
Journal title
AUSTRALIAN JOURNAL OF CHEMISTRY
ISSN journal
00049425 → ACNP
Volume
53
Issue
3
Year of publication
2000
Pages
171 - 174
Database
ISI
SICI code
0004-9425(2000)53:3<171:ANPOTD>2.0.ZU;2-H
Abstract
Acylation of the alditols (2) obtained by sodium borohydride reduction of N -acetylneuraminic acid (Neu5Ac) (1) gives a mixture of lactones (3) and (4) which can be separated and deprotected without epimerization yielding pure samples of the diastereoisomeric N-acetylneuraminic alditols (5) and (6).