Transforming growth factor-beta(1) increases the expression of lectin-likeoxidized low-density lipoprotein receptor-1

Lectin-like oxidized low-density lipoprotein (Ox-LDL) receptor-1 (LOX-1) is a novel cell-surface receptor for Ox-LDL, which can be expressed by vascul ar endothelial cells, smooth muscle cells, and macrophages. On the other ha nd, transforming growth factor (TGF)-beta(1), which plays crucial roles in vascular remodeling and the pathogenesis of atherosclerosis, has been shown to inhibit expression of class A scavenger receptors and CD36 in macrophag es. Here we provide the evidence that TGF-beta(1) (0.1-10 ng/mL) induces LO X-1 protein and mRNA expression in both bovine aortic endothelial cells and smooth muscle cells in a dose- and time-dependent fashion, probably at the transcriptional level. TGF-beta(1) also upregulates LOX-1 mRNA expression in murine peritoneal macrophages. Thus TGF-beta(1) can highly induce LOX-1 expression in vascular endothelial cells, smooth muscle cells, and macropha ges, suggesting that TGF-beta(1) appears one of the key regulators that mod ulates expression of scavenger receptors. (C) 2000 Academic Press.