Studies on hepatic gene expression in different liver regenerative models

Citation
P. Nagy et al., Studies on hepatic gene expression in different liver regenerative models, BIOC BIOP R, 272(2), 2000, pp. 591-595
Citations number
27
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN journal
0006291X → ACNP
Volume
272
Issue
2
Year of publication
2000
Pages
591 - 595
Database
ISI
SICI code
0006-291X(20000607)272:2<591:SOHGEI>2.0.ZU;2-R
Abstract
We have investigated the expression of several growth-related genes in the liver after partial hepatectomy in three experimental models: normal, Dexam ethasone-pretreated, and hypophysectomized rats. Dexamethasone and hypophys ectomy resulted in a delay in the peak of cell replication in 6 and 18 h, r espectively, when compared to the normal animals. TGF alpha mRNA expression was shifted together with the DNA synthesis, but the expression of c-myc, c-fos, c-jun, HGF, TGF beta 1, IL1 beta did not delay, This result suggests that liver-derived TGF alpha but not the other factors are important in th e timing of the proliferative response after partial hepatectomy. (C) 2000 Academic Press.