Antifungal rapamycin analogues with reduced immunosuppressive activity

Authors
Dickman, DA Ding, H Li, Q Nilius, AM Balli, DJ Ballaron, SJ Trevillyan, JM Smith, ML Seif, LS Kim, K Sarthy, A Goldman, RC Plattner, JJ Bennani, YL
Citation
Da. Dickman et al., Antifungal rapamycin analogues with reduced immunosuppressive activity, BIOORG MED, 10(13), 2000, pp. 1405-1408
Citations number
27
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
13
Year of publication
2000
Pages
1405 - 1408
Database
ISI
SICI code
0960-894X(20000703)10:13<1405:ARAWRI>2.0.ZU;2-O
Abstract
Several 1,2,3,4-tetrahydro- and 7-N-hydroxycarbamate derivatives of the nat ural product rapamycin were prepared and assayed for their immunosuppressiv e and antifungal profiles. Substitutions at the 7-position indicate the pos sibility of a differentiated immunosuppressive to antifungal profile, where as 40-position variants of the tetrahydro-analogues did not show similar di fferentiated activity. (C) 2000 Published by Elsevier Science Ltd. All righ ts reserved.