Synthesis of tetrakis(multifluoro-4-pyridyl)porphin derivatives as acetylcholinesterase inhibitors

Authors
Moon, SC Shin, JH Jeong, BH Kim, HS Yu, BS Lee, JS Lee, BS Namgoong, SK
Citation
Sc. Moon et al., Synthesis of tetrakis(multifluoro-4-pyridyl)porphin derivatives as acetylcholinesterase inhibitors, BIOORG MED, 10(13), 2000, pp. 1435-1438
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
13
Year of publication
2000
Pages
1435 - 1438
Database
ISI
SICI code
0960-894X(20000703)10:13<1435:SOTDAA>2.0.ZU;2-B
Abstract
New tetrakis(multifluoro-4-pyridyl)porphin derivatives (2-4) and water solu ble porphyrin (5) were synthesized to investigate their interactions with a cetylcholinesterase from electric eel. These compounds have been found to b e the potent reversible inhibitors of the enzyme with K-i values of mu M ra nge. In addition, porphyrin (5) showed broad spectrum of anticancer activit ies. (C) 2000 Elsevier Science Ltd. All rights reserved.