Purpurinimides as photosensitizers: Effect of the presence and position ofthe substituents in the in vivo photodynamic efficacy

Authors
Rungta, A Zheng, G Missert, JR Potter, WR Dougherty, TJ Pandey, RK
Citation
A. Rungta et al., Purpurinimides as photosensitizers: Effect of the presence and position ofthe substituents in the in vivo photodynamic efficacy, BIOORG MED, 10(13), 2000, pp. 1463-1466
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
13
Year of publication
2000
Pages
1463 - 1466
Database
ISI
SICI code
0960-894X(20000703)10:13<1463:PAPEOT>2.0.ZU;2-G
Abstract
This study presents a novel approach for the regioselective synthesis of a series of alkyl ether analogues of purpurin-18-N-alkylimide. In the purpuri nimide series, this is the first example which demonstrates that the presen ce and position of the substituents in the macrocycle makes a remarkable di fference in the in vivo PDT efficacy. (C) 2000 Elsevier Science Ltd. All ri ghts reserved.