Design and evaluation of dihydroisoquinolines as potent and orally bioavailable human cytomegalovirus inhibitors

Authors
Chan, L Stefanac, T Turcotte, N Hu, ZH Chen, YM Bedard, J May, S Jin, HL
Citation
L. Chan et al., Design and evaluation of dihydroisoquinolines as potent and orally bioavailable human cytomegalovirus inhibitors, BIOORG MED, 10(13), 2000, pp. 1477-1480
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
13
Year of publication
2000
Pages
1477 - 1480
Database
ISI
SICI code
0960-894X(20000703)10:13<1477:DAEODA>2.0.ZU;2-X
Abstract
Following the identification of first pass metabolism issues with our recen tly described anti-HCMV compounds, the naphthyridines and isoquinolines, we have designed a class of novel metabolically stable and orally bioavailabl e anti-HCMV agents, the dihydroisoquinolines. (C) 2000 Elsevier Science Ltd . All rights reserved.