A model for Zn-II-containing-beta-lactamase: Synthesis, x-ray crystal structure of a zinc(II) complex bearing thiol group and hydrolysis of phosphatediester

Authors
Kurosaki, H Tawada, T Kawasoe, S Ohashi, Y Goto, M
Citation
H. Kurosaki et al., A model for Zn-II-containing-beta-lactamase: Synthesis, x-ray crystal structure of a zinc(II) complex bearing thiol group and hydrolysis of phosphatediester, BIOORG MED, 10(12), 2000, pp. 1333-1337
Citations number
23
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
12
Year of publication
2000
Pages
1333 - 1337
Database
ISI
SICI code
0960-894X(20000619)10:12<1333:AMFZSX>2.0.ZU;2-Y
Abstract
A novel N3S1 typed tripodal ligand bearing an SH group, N-(mercaptoethyl)-d i(2-pyridylmethyl)amine DPASH, was prepared and its zinc(II) complex, [Zn-I I(DPAS)CI], was structurally characterized by X-ray crystallography. [Zn-II (DPAS)CI] promoted hydrolysis of sodium bis(p-nitrophenyl)hydrogenphosphate ), BNP-. (C) 2000 Elsevier Science Ltd. All rights reserved.