Solid-phase synthesis of muramyl dipeptide (MDP) derivatives using a multipin method

Authors
Liu, G Zhang, SD Xia, SQ Ding, ZK
Citation
G. Liu et al., Solid-phase synthesis of muramyl dipeptide (MDP) derivatives using a multipin method, BIOORG MED, 10(12), 2000, pp. 1361-1363
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
12
Year of publication
2000
Pages
1361 - 1363
Database
ISI
SICI code
0960-894X(20000619)10:12<1361:SSOMD(>2.0.ZU;2-R
Abstract
Solid-phase synthetic method of muramyl dipeptide derivatives is reported. A diverse library of muramyl dipeptides could be potentially synthesized by acylation, reductive alkylation, sulfonamide formation, urea formation, N- alkylation, amine addition, or component Ugi reactions based on this method for drug screening. (C) 2000 Elsevier Science Ltd. All rights reserved.