Synthesis and cytotoxic activity of acetogenin analogues

Authors
Rodier, S Le Huerou, Y Renoux, B Doyon, J Renard, P Pierre, A Gesson, JF Gree, R
Citation
S. Rodier et al., Synthesis and cytotoxic activity of acetogenin analogues, BIOORG MED, 10(12), 2000, pp. 1373-1375
Citations number
23
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
12
Year of publication
2000
Pages
1373 - 1375
Database
ISI
SICI code
0960-894X(20000619)10:12<1373:SACAOA>2.0.ZU;2-6
Abstract
A set of 16 new simplified analogues of acetogenins has been designed based on: (i) the replacement of the bis THF moiety of these natural products by an ethylene glycol bis ether unit; (ii) the introduction of different lipo philic side chains (alkyl, aryl, dialkylamino, O-cholesteryl); (iii) the pr esence of the same terminal isolactone. In vitro cytotoxic activity against L1210 leukemia is reported. (C) 2000 Elsevier Science Ltd. All rights rese rved.