Citation
P. Borusiak et al., Seizure-inducing paradoxical reaction to antiepileptic drugs, BRAIN DEVEL, 22(4), 2000, pp. 243-245
Citations number
7
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
BRAIN & DEVELOPMENT
ISSN journal
03877604
→ ACNP
Volume
22
Issue
4
Year of publication
2000
Pages
243 - 245
Database
ISI
SICI code
0387-7604(200006)22:4<243:SPRTAD>2.0.ZU;2-E
Abstract
We report on an 18-month-old girl with a seizure frequency of five/day, rec
eiving an antiepileptic polytherapy consisting of primidone, clonazepam and
phenytoin. Following discontinuation of clonazepam and primidone, the pati
ent has been seizure-free under monotherapy for 2 years and shows marked de
velopmental progress. Possible mechanisms of this paradoxical effect of ant
iepileptic drugs and the implications for antiepileptic therapy are discuss
ed. (C) 2000 Elsevier Science B.V. All rights reserved.