Analysis of EEG data from weak-field magnetic stimulation of mesial temporal lobe epilepsy patients

Ten patients suffering from mesial temporal lobe epilepsy were exposed to w eak, DC magnetic field stimulation following computer-controlled protocols established in previous studies. Poisson statistical analysis of the ten pa tients undergoing semi-invasive (foramen ovale) electrode monitoring reveal s that for at least one experimental protocol, application of DC magnetic f ields alters interictal epileptiform spike activity in five of ten patients . Similar results also have been observed in the analysis of both human and rat brains by employing weak, alternating magnetic field stimulation. Furt her study is necessary in order to optimize the magnetic field exposure pro tocol. (C) 2000 Elsevier Science B.V. All rights reserved.