Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist

Authors
Murakami, M Nakagawasai, O Fujii, S Hosono, M Hozumi, S Esashi, A Taniguchi, R Okamura, T Suzuki, T Sasano, H Yanagisawa, T Tan-No, K Tadano, T Kitamura, K Kisara, K
Citation
M. Murakami et al., Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist, BRAIN RES, 868(1), 2000, pp. 123-127
Citations number
20
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
868
Issue
1
Year of publication
2000
Pages
123 - 127
Database
ISI
SICI code
0006-8993(20000616)868:1<123:AEOCAN>2.0.ZU;2-A
Abstract
We investigated the antinociceptic effects of cilnidipine, a dihydropyridin e derivative which acts on both L- and N-type voltage-dependent calcium cha nnels, in mice. Intrathecally injected cilnidipine showed significant analg esic effect in formalin test. Cilnidipine significantly suppressed N-type c urrents in dorsal root ganglion (DRG) cells. Our findings apparently suppor t the idea that cilnidipine attenuates synaptic neurotransmission by inhibi ting N-type calcium channels in DRG neurons. (C) 2000 Elsevier Science B.V. All rights reserved.