C-Nociceptor sensitization by isoprostanes is cyclooxygenase dependent

Isoprostane E-2 (8-iso-PGE) and F-2 alpha (8-iso-PGF) sensitize nociceptors and capsaicin-sensitive DRG neurons. In this study we investigated the cyc looxygenase-dependence of isoprostane-induced C-nociceptor sensitization. S ystemic pretreatment of rats with ketorolac (1 and 10 mg/kg) abolished 8-is o-PGF sensitization and reduced the effects of 8-iso-PGE. Ibuprofen (30 mg/ kg) blocked all sensitizing effects. These data suggest that some algesic p roperties of isoprostanes are mediated via prostanoid synthesis. (C) 2000 E lsevier Science B.V. All rights reserved.