ROLE OF GAMMA-INTERFERON IN THE PATHOGENESIS OF BACTEREMIC PNEUMOCOCCAL PNEUMONIA

Authors
RUBINS JB POMEROY C
Citation
Jb. Rubins et C. Pomeroy, ROLE OF GAMMA-INTERFERON IN THE PATHOGENESIS OF BACTEREMIC PNEUMOCOCCAL PNEUMONIA, Infection and immunity, 65(7), 1997, pp. 2975-2977
Citations number
23
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
65
Issue
7
Year of publication
1997
Pages
2975 - 2977
Database
ISI
SICI code
0019-9567(1997)65:7<2975:ROGITP>2.0.ZU;2-5
Abstract
Gamma interferon (IFN-gamma) concentrations in blood, but not in lungs , rose significantly at 24 to 48 h after murine pulmonary infection wi th virulent pneumococci. In contrast, infection with avirulent pneumoc occal strains produced minimal rises in serum IFN-gamma concentrations . Compared with that of immunocompetent mice, mortality was appreciabl y increased after pulmonary infection of IFN-gamma gene knockout mice, suggesting a protective role for IFN-gamma in host response to pneumo coccal disease.