A versatile approach to the total synthesis of the pseudomonic acids

Authors
Mckay, C Simpson, TJ Willis, CL Forrest, AK O'Hanlon, PJ
Citation
C. Mckay et al., A versatile approach to the total synthesis of the pseudomonic acids, CHEM COMMUN, (13), 2000, pp. 1109-1110
Citations number
27
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
13
Year of publication
2000
Pages
1109 - 1110
Database
ISI
SICI code
1359-7345(2000):13<1109:AVATTT>2.0.ZU;2-9
Abstract
The total synthesis of pseudomonic acid C is described using an approach wh ich gives access to analogues and putative biosynthetic precursors; the key step is installation of the C-7 side-chain via alkylation of a trisubstitu ted delta-lactone with complete stereocontrol and in 85% yield under condit ions which avoid the possible competing elimination of a protected hydroxy group beta to the carbonyl.