Hydroxamic acids are nitric oxide donors. Facile formation of ruthenium(II)-nitrosyls and NO-mediated activation of guanylate cyclase by hydroxamic acids

Authors
Marmion, CJ Murphy, T Docherty, JR Nolan, KB
Citation
Cj. Marmion et al., Hydroxamic acids are nitric oxide donors. Facile formation of ruthenium(II)-nitrosyls and NO-mediated activation of guanylate cyclase by hydroxamic acids, CHEM COMMUN, (13), 2000, pp. 1153-1154
Citations number
15
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
13
Year of publication
2000
Pages
1153 - 1154
Database
ISI
SICI code
1359-7345(2000):13<1153:HAANOD>2.0.ZU;2-G
Abstract
Hydroxamic acids are shown for the first time to be effective NO donors by their ability to readily form ruthenium(II)-nitrosyls, and to cause vascula r relaxation of rat aorta by NO-mediated activation of the iron-containing guanylate cyclase.