Thermodynamic study on separation of molecular imprinting chiral stationary phase

The effect of temperature on the chiral separation of the molecular imprint ing polymer was investigated and the thermodynamic parameters were calculat ed, It was found that the chiral separation process was enthalpy-controlled . Increasing the temperature decreases the capacity factor and chiral selec tivity factor. The interactions between the analyte and the molecular impri nting chiral stationary phase were both non-specific and specific, and only the difference of specific interaction results in the chiral separation. T he imprinting cavities affected the thermodynamic parameters dramatically, The rebinding of the imprinted molecule into the imprinting cavities was fa vorable in view of energy and configuration because of their best compatibl eness.